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In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

Itinerary Day 1: Cusco Urcos Tinqui In the morning, we take our transport to the city of Tinqui

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

Type 2 diabetes is a chronic and progressive condition in which the body does not make or use insulin properly, leading to high levels of glucose (sugar) in the blood