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Moreover, both GLP-1 (70) and GLP-1RAs [eg, exenatide (71), albiglutide (72), and liraglutide (73)] have been shown to inhibit gallbladder emptying and refilling and to potentially reduce the discharge of bile into the small intestine, interrupting the subsequent emulsification and digestion of dietary lipids
The additional GIP receptor agonism appears to augment insulin secretion further and may contribute to improved lipid metabolism and enhanced satiety signaling
