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Chemicals Unless otherwise indicated, the chemicals, culture medium, and supplements used in this study were purchased from Sigma-Aldrich (Shanghai, China) and Thermo Fisher (Beijing, China)

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The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN

Methods In this open-label, non-randomized, single-arm trial, 34 participants with migraine with aura received continuous intravenous infusion of CGRP (1.5 g/min) over 20 min on a single experimental day

A few years later, scientists from the pharma company Amgen also raised doubts, claiming Sinclairs findings were erroneous