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When teeth are lost, the jawbone beneath begins to shrink over time due to lack of stimulation, making it harder for dentures to fit snugly

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PDGF is secreted by activated platelets, endothelial, epithelial, glial cells as well as inflammatory cells and it targets a broad spectrum of cell type including, fibroblasts, pericytes, smooth muscle cells, glial cells or mesangial cells [140]

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