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67 A Bayesian network meta-analysis pooled data from 54 RCTs involving 49 602 participants, of whom 28 353 received GLP-1 RA treatment demonstrated that GLP-1 RAs were associated with a reduced risk of fractures compared to placebo or other antihyperglycemic agents

We know eating an adequate protein around 1 gram per pound body weight or goal weight- even when your overall caloric intake is not optimal- insures that muscle is preserved (Longland et al, 2016)

Parts of this study were presented in Poster 710 at the 50th EASD Annual Meeting in 2014, Vienna, 1519 September 2014

For constipation, water softens stool and supports motility

The first pathway is reduced intake