According to Mayo Clinics drug and supplement reference, intramuscular B12 (the form used in MIXTs B12 injection protocols) is well-established for restoring B12 status quickly in clinically deficient patients and is often used when oral supplementation is poorly absorbed
Reduced effectiveness: If your typical dose seems less effective than previous weeks from the same vial, potency may have decreased
Other Uses Compounded methylcobalamin injections and other forms of vitamin B12 injections like hydroxocobalamin and cyanocobalamin may also be prescribed for those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma
Dose-Response Patterns Mouse studies tested 20 mg/kg subcutaneous, three injections per day
Follow the written protocol for site selection and rotation [15]
