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doi:10.1159/000053183 Heffernan MA, Thorburn AW, Fam B, et al

In addition to decreased downstream hormone levels, low DHEA may be associated with aging, fatigue, increased cardiovascular disease, bone loss, low libido, erectile dysfunction in men, and cognitive performance

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The authors also highlight the safety of repeated intranasal use and encourage long-term studies assessing neurodegeneration and synaptic health

But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address