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Similarly, in the human chondrocyte SW1353 cell line, dulaglutide inhibited AGEs-induced activation of NFkB and the expression of pro-inflammatory cytokines [99], whilst in human knee OA primary articular chondrocytes, lixisenatide reduced mRNA ad protein expression of TNF-, IL-6 and IL-7 [100]

Tangent In clinical trials for semaglutide and liraglutide, patients were excluded from studies if they had a history of suicidal attempts, suicidal behavior within 30 days of screening, a history of depression within two years of screening and diagnosis of any severe mental health disorder, like schizophrenia or bipolar disorder

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Anyone with a history of hypersensitivity reactions to melanocortin-based compounds should discuss this with a US-licensed provider before use

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