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This depletion compromises cellular defense mechanisms and contributes to numerous age-related pathologies including neurodegenerative diseases, cardiovascular dysfunction, metabolic disorders, and impaired immune function

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Diagnosis is made by the finding of a diffuse, smooth, firm goiter in a young woman, with strongly positive titers of TG Ab and/or TPO Ab and a euthyroid or hypothyroid metabolic status

doi: 10.1016/0169-328X(94)90054-X 24 BoghozianR.SharmaS.NarayanaK.CheemaM.BrownC

*Correspondence: Yaguang Wu, [email protected] Sun, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers