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Progress of AstrocyteNeuron Crosstalk in Central Nervous System Diseases. Neurochemical Research 49: 31873207

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The approval of XPOVIO was based upon the efficacy and safety in a prespecified subgroup analysis of the 83 patients whose disease was refractory to bortezomib, carfilzomib, lenalidomide, pomalidomide, and daratumumab, as the benefit-risk ratio appeared to be greater in this more heavily pretreated population than in the overall trial population

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While animal studies cannot definitively rule out human cancer concerns, the consistent absence of tumors or pre-cancerous changes across multiple species, dosing regimens, and administration routes carries meaningful weight