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3.1.1 Preclinical evidence Administration of metformin before ischemia or at reperfusion reduces myocardial injury in diabetic and non-diabetic models without altering blood glucose

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There is a synergic interaction between TRPA1 and TRPV1 on channel activation mechanisms in DRG, because TRPA1 is co-localized with 3050% TRPV1 expressing neurons in rat and human DRG (Bautista et al., 2016

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In addition, their anti-inflammatory properties play a key role in regulating vascular remodeling, optimizing cerebral blood flow and ensuring nutrient delivery to support neuronal functions