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In addition, one study that evaluated cortical volumes in MS by MRI reported that cortical atrophy is also more extensive in male compared to female patients, but only when the studied females were restricted to those having a pre-menopausal MS onset (68), pointing to ovarian hormones as protective factors against neurodegeneration in MS

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Moreover, the method of administration (initially parenteral followed by oral in [54] versus oral only in [55]) and length of treatment (4 months in [54] versus 2 months in [55]) were different

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