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This dual agonism enhances insulin secretion in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia

These include obesity, high blood pressure, and diets high in red meat or processed foods

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Most common is the use of 2-deoxy-2-(18F) fluoro-D-glucose positron emission tomography (PET), which measures energy demand by trapping a non-metabolizable glucose analog that carries a PET label

Data availability The datasets analyzed during the current study are not publicly available due to concerns regarding participant privacy and consent, but are available from the corresponding author upon reasonable request