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J Pharmacol Sci 2008

Gastrointestinal and Cytoprotective Investigations Given its origin as a fragment of a gastric peptide, it is no surprise that BPC-157's effects on the GI tract have been extensively studied

However, treatment with disulfiram and metformin increased the abundance of intestinal Akkermansia bacteria, decreased serum IFN- levels, and inhibited the pyroptosis in ovarian macrophages, thereby improving PCOS symptoms (173)