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The depletion of glutathione also plays a critical role in the exacerbation of mast cell activation syndrome (MCAS) and dysautonomia, including postural orthostatic tachycardia syndrome (POTS)

Existing biomarkers mainly reflect systemic iron metabolism or oxidative stress, and have limited information on kidney-specific ferroptotic events ( 6 Conclusion Experimental evidence suggests that SGLT2 inhibitors may inhibit ferroptosis through the regulation of iron balance, lipid metabolism, and antioxidant systems

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