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MT-II is a cyclic heptapeptide broadly activating MC1R, MC3R, and MC4R , simultaneously producing melanogenesis alongside central pro-sexual, pro-erectile, and anorectic effects through hypothalamic MC3R/MC4R activation, Cyclisation of the -MSH pharmacophore core is the primary structural determinant of this receptor subtype selectivity shift

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PMCID:PMC2596047

doi: 10.3390/biom10081176 24 NairzMDichtlSSchrollAHaschkaDTymoszukPTheurlIet al

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