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Nature 496(7443):101105 Sourbier C, Ricketts CJ, Liao PJ et al (2019) Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

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Mechanism of Action When GLP-1 peptides are administered, they bind to the GLP-1 receptors in the brain, pancreas, and gastrointestinal tract, leading to several key effects: Increased Insulin Secretion: Enhances insulin release in response to meals

Warnings: Thyroid Tumors: Contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

10.1093/toxsci/kfx230 37 WeiM.GuX.LiH.ZhengZ.QiuZ.ShengY.et al (2023)