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Its a careful titration process, really

Toot S, Swinson T, Devine M, Challis D, Orrell M

156,157 During these processes, Sirt1/6 deacetylases also regulate metabolism, reducing glycolysis and increasing fatty acid oxidation coupling metabolism with the inflammatory response

This can lead to aesthetic concerns like Ozempic Face. If you are a patient, always work with a doctor