GLP-1RAs suppress the progression of atherosclerosis in ApoE -/- , LDLr -/- , and even in moderate uremia LDLr -/- mice[16, 60]
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Kuraji M, Matsuno T, Satoh T (2016) Astaxanthin affects oxidative stress and hyposalivation in aging mice
What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
Lowered inhibitions Slurred speech Poor coordination Confusion Memory loss Difficulty concentrating Difficulty breathing