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A recent study has examined the effect of cobalamin supplementation on the outcomes of treatment for feline patients with severe cobalamin deficiency and histories suggesting chronic gastrointestinal disease.5 In this study, serum concentrations of methylmalonic acid normalized following parenteral cobalamin supplementation, indicating that cobalamin deficiency was the cause of the high methylmalonic acid in serum

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Saline (0.9% sodium chloride) is another option sometimes mentioned, but it can occasionally cause peptide aggregation or affect solubility, depending on the specific amino acid sequence