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These cells detect the presence of nutrients in the intestinal lumen via chemosensory G protein-coupled receptors (GPCRs) and taste receptors , and in response, release hormones that influence digestion , appetite , and glucose metabolism

The most common side effects are gastrointestinal symptoms, which can typically be managed with slow dose titration and ongoing dialogue with your physician

But if you stop taking GLP-1 medicine and then gain weight, the fat cells in your body can grow, which can make you gain weight in regions that arent being treated

Appetite Regulation Studies Investigation of satiety pathway influence and neuroendocrine effects

If renal function does reduce, it may be of value to discuss side effects experienced with the patient and reiterate the importance of maintaining adequate fluid intake when unwell