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Some individuals find that taking concentrated antioxidants on an empty stomach leads to mild nausea or a "heavy" feeling in the gut

This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine

B12 also facilitates energy transport around the body via its involvement in the ATP (adenosine triphosphate) cycle, which is vital for many other cellular functions

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