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Pcsk5 ECKO mice and Pcsk5 WT littermate controls showed no significant differences in cardiac function, myocardial capillary, and arteriole density, or plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) (Fig

Despite being designed before the emergence of several variants, including Delta and Omicron, the antigen induces cross-reactive nAb to these and several tested sarbecoviruses in mice, rabbits, and guinea pigs [152]