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Holst JJ, Deacon CF (1998) Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

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Some common side effects are: Digestive issues and nausea: Because GLP-1 slows digestion, food sitting in the stomach for longer periods of time can cause nausea or digestive discomfort Nutritional deficiencies: With appetite suppressants come less food intake, theres a risk of not getting enough of the vitamins and minerals that our bodies still need Low energy or fatigue: Some people may experience fatigue while taking GLP-1 but this effect is typically brief