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Histological findings further supported these outcomes, revealing an increase in body weight, which had been decreased by the induction of colitis

Although endothelial activation and redox signaling compose a normal host defense, when this activation is sustained, chronic production of ROS may exceed the capacity of cellular enzymatic and nonenzymatic antioxidant defenses [49], contributing to triggering vascular diseases such as atherosclerosis or peripheral artery disease [102, 103]

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