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The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)

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A flawed reconstitution process can introduce contaminants or begin the degradation process before the peptide is even fully dissolved

If nausea persists beyond four weeks despite timing changes, reduce your dose by 2550 mcg or split your total weekly dose into smaller, more frequent administrations (e.g., five days per week at lower dose instead of seven)

15,272 GLP-1RAs and joint disorders GLP-1RAs in OA GLP-1R expression was detected via immunohistochemistry in articular chondrocytes from both normal and osteoarthritic individuals