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Less Common but More Serious Risks Although uncommon, semaglutide may be associated with: Pancreatitis Gallbladder problems Kidney complications related to dehydration Changes in blood sugar levels Possible risk of thyroid C-cell tumors (observed in animal studies) Semaglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

When used at its proper dosage accompanied by a balanced diet and regular physical activity, Semaglutide GLP-1 injections have been reported to show 15% to 18% of weight loss in patients, which is higher than most other medical weight loss medications that are commonly used

doi:10.7150/jca.98844 This issue Cite Research Paper 1

The failure was related to efficacy, not major safety concerns

H2-receptor antagonists (like famotidine) or proton pump inhibitors (PPIs such as omeprazole or esomeprazole) offer more sustained acid suppression for frequent or severe symptoms