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Kidneys: NAD+ therapy may help to protect the kidneys from damage

Since you are likely eating smaller portions, prioritizing protein (to preserve muscle) and fiber (for digestion) is essential

Their website references a 6-month clinical trial of 180 participants taking semaglutide or tirzepatide alongside the WW Clinic programme (Heinberg et al.)

The STEP (Semaglutide Treatment Effect in People with Obesity) clinical trial programme demonstrated that adults using semaglutide 2.4 mg weekly alongside lifestyle intervention lost an average of approximately 15% of their body weight over 68 weeks, compared to around 2.4% with placebo. NICE approved Wegovy for use in specialist weight management services in the UK in 2023 (TA875), recognising its clinical effectiveness. Ongoing research continues to explore its cardiovascular benefits, with the SELECT trial showing a significant reduction in major cardiovascular events in people with obesity

Anecdotally, some people who switched from semaglutide to tirzepatide report that their appetite, which had started returning somewhat on semaglutide, decreased again on tirzepatide