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Drug concentrations are affected by the abnormal and immature tumor vasculature system, as well as by the activation of drug efflux transporters under the hypoxic tumor environment 52

Fasted-state administration (8+ hours without food) suppresses insulin and activates AMPK, triggering maximum autophagy flux and cellular permeability

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Microdosing typically uses lower doses than those prescribed for diabetes or weight management, focusing instead on promoting daily wellness and metabolic balance