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Therefore, overall exendin-P5 forms relatively stable interactions with the ECD, upper portion of TM1, TM2 and TM7, and with ECL1 and ECL2, however interactions with key residues deeper in TM2, TM3, TM5, TM6, TM7, as well as with ECL3, are transient, the majority of them present for less than 20 % of the frames measured within the MD simulation (Supplemental Figure 11, Supplemental Table 3)

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