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Salvianolic acid B modulates the expression of drug-metabolizing enzymes in HepG2 cells

This could be due to two factors: Selection Bias: Patients prescribed 20 mg often have more severe underlying vascular disease (which necessitates the higher dose), potentially skewing their mortality risk higher regardless of the drug

Some peptide breakdown products retain partial activity while others become inactive

[DOI] [PubMed] [Google Scholar] 15.Nauck MA, Niedereichholz U, Ettler R, et al

Reasons it was discontinued (business, not safety) The decision to discontinue the commercial production of sermorelin was based on business reasons, not on its safety profiles