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Notably, More recent studies suggest that PYY signaling interacts synergistically with GLP-1 and other satiety peptides, raising the possibility that lower-dose combination strategies could harness its anorectic effects while minimizing intolerance ( 5.2 Oxyntomodulin as an endogenous polypharmacologic signal As discussed in Section 4.4, it also plays a central role in appetite regulation in the context of metabolic peptides

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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Aengenheister L., Favaro R.R., Morales-Prieto D.M., Furer L.A., Gruber M., Wadsack C., Markert U.R., Buerki-Thurnherr T