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Deficiency of G6PD in the alternative pathway causes the buildup of glucose, and thus an increase of advanced glycation endproducts (AGE)

.,SinghJ,KaurS,KaurMVermaMKThe role of uric acid as an antioxidant in selected neurodegenerative disease pathogenesis.2022;9(4):239247 21

This review highlights the limitations of conventional approaches and explores alternative strategies, including LT4+LT3 combination therapy, total thyroidectomy, and adjunctive treatments such as supplements, herbal medicine, and acupuncture

Contributing mechanisms include direct tubular toxicity of snake venom metalloproteinases and phospholipase A2, intravascular haemolysis with haemoglobinuria, rhabdomyolysis with myoglobinuria, disseminated intravascular coagulation (DIC) with intrarenal microthrombosis, and pre-renal injury secondary to hypotension and third-space fluid losses

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