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For example, medical conditions were self-reported, whereas Bessette and Anderson were unable to measure all trial exclusion criteria with accurate temporality, which may underestimate the proportion excluded. Bessette said that primary care providers should consider screening for depression, liver function, and concomitant use of medications that delay gastric emptying before prescribing medications like GLP-1 receptor agonists

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Research in this pediatric age group remains limited, although one randomized study found that teens using semaglutide lost about 17% of their starting weight after one year, compared to 3% to 4% with lifestyle modification alone