Betaine, also known as trimethylglycine, is a naturally occurring metabolite that serves as a methyl donor and osmolyte in the body
For example, air pollution, smoking, pneumonia, and diseases such as asthma, COVID-19, and chronic obstructive pulmonary disease (COPD) can all contribute to decreased lung function ( Additionally, dietary choices and micronutrient deficiencies may negatively affect lung function ( Some research suggests that certain dietary supplements, such as vitamins and minerals, may help people with medical conditions that affect lung function, as well as those who wish to support their lung health in general
As with all drugs in this class, side effects involving the digestive system, kidneys or liver may occur
Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated average reductions in body weight exceeding 20% over 48 weeks in some participants
In line, Prx6 knockout mice exhibit markedly reduced levels of GPX4 and other selenoproteins, with this decrease being particularly pronounced in the brain [177] , highlighting the critical role of this redoxin in selenium metabolism and providing a missing link in selenoprotein biology that explains how cells coordinate thiol and selenium metabolism to counteract lipid peroxidation
