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(b) Single small case series in knee pain A peer-reviewed article (Lee et al., Alternative Therapies in Health & Medicine , ~2021) describes: 12 patients with chronic knee pain Treated with intra-articular BPC-157, often combined with TB-500 7 of 12 reported symptom improvement lasting several months This study has major limitations: No control group No blinding No standardized outcomes (no KOOS, WOMAC, or imaging) Very small sample size Mixed interventions Conclusion: This study cannot demonstrate true benefit

found that hypoxia can drive the production of CXCL4 in MS patients plasmacytoid dendritic cells by stabilizing HIF-2 through excessive production of mtROS ( P =0.0079) (166)

Open field test (OF) The Open field apparatus was a square arena (80 80, 50 cm high wall) made of black acrylic and brightly illuminated