GH is secreted by somatotroph cells in the anterior pituitary, which plays a key role in endocrine regulation of GH production and secretion
Currently, PAAD is mainly treated by surgery and radiotherapy, but problems such as chemotherapeutic drug resistance have led to a generally poor prognosis for patients, and some studies have confirmed that the development of chemotherapeutic drug resistance is closely related to apoptosis [2], so inducing non-apoptotic cells to die may provide an alternative therapeutic strategy for resisting apoptotic drug resistance
Biorg Med Chem 25:61806189 Bekaii-Saab T, Wesolowski R, Ahn DH, Wu C, Mortazavi A, Lustberg M, Ramaswamy B, Fowler J, Wei L et al (2019) Phase I immunotherapy trial with two chimeric HER-2 B-cell peptide vaccines emulsified in montanide ISA 720VG and nor-MDP adjuvant in patients with advanced solid tumors phase I immunotherapy trial with two B-cell vaccines
Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid
Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state
