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Studies have shown that Xiaoyao Pill upregulates the expression of DNMT1 in patients with depression, salvaging the abnormal gene expression and DNA methylation patterns associated with depression [2, 526]

Nrf2 regulates enzymes responsible for GSH syntheses, such as the glutamate-cysteine catalytic subunit (GCLC) and glutamate-cysteine ligase modifier subunit (GCLM), and enzymes related to GSH utilization, such as glutathione S transferase (GST), glutathione peroxidase, and glutathione reductase [54]

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30 mL multi-dose bacteriostatic water, third-party tested