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Because human research is limited, many safety questions remain unanswered

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When they are impaired because of nutrient deficiencies, genetic variation, or other metabolic disturbances, homocysteine levels rise, making it a clinically useful marker of impaired one carbon metabolism

61,62,63,64 Additionally, emerging evidence suggests that virus infections, such as COVID-19, exacerbate neuropathies in diabetes patients through inflammatory and immune-mediated mechanisms