Convincing data with sufficient power to detect the risk/benefit profile of their use remain to be illustrated
It is unknown whether SAXENDA will cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of liraglutide-induced rodent thyroid C-cell tumors has not been determined
It confirmed the tanning effect, but also multiple unexpected side effects that led to the development bifurcation (PT-141 for sexual function, Afamelanotide for cutaneous indications)
In the future, a multidimensional line of evidence is needed to clarify the source of GLP-1RA effects in IBD, including in vitro experiments to confirm direct actions, animal models designed to exclude metabolic interference, and clinical data adjusted for metabolic confounders
1.10 Hashimotos thyroiditis and environmental factors Of those shown in Fig