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Interestingly, in individuals with ALDH2 deficiency, serum cortisol and corticosterone levels also declined to normal levels 60 min post drinking, but further elevated again at later time points with a peak occurring at 180 min post drinking

It is naturally present in human blood, saliva, urine, and its plasma concentration declines with age from approximately 200 ng/mL at age 20 to under 80 ng/mL after age 60