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If one anatomical area (abdomen, thigh, or upper arm) consistently causes more discomfort, focus on the better-tolerated sites while maintaining proper rotation within that area

4 Comparison of change from baseline by week for selected cardiometabolic endpoints for semaglutide versus placebo

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The key findings provide the most reliable timeline for expected results: Week 4: Average weight loss of approximately 1 to 2% of body weight Week 12: Average weight loss of approximately 5 to 6% of body weight Week 20: Average weight loss of approximately 10% of body weight Week 40: Average weight loss of approximately 13 to 14% of body weight Week 68: Average weight loss of approximately 15 to 17% of body weight These are averages, meaning some participants lost more and some lost less