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Some individuals experience injection site reactions or sensitivity to components of the injection

Systemic side effects (nausea, vomiting, reduced appetite) are dose-dependent and typically diminish over time

Dose Tolerance and Missed Doses If patients do not tolerate the 25 mg once-daily pill, consider switching to the once-weekly Wegovy pen 1.7 mg

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The 2020 systematic review by Galeano and colleagues across 34 eligible studies confirmed the mechanism: PDRN promotes physiological tissue repair through salvage-pathway nucleotide recycling and A2A receptor activation [32]