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In these cases, intravenous B12 administration via injection is not just preferable it is essential

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For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells ( In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance (Luis Garcia-Gimenez et al., 2013)

A few have real human evidence, usually outside the brain, and most have little brain evidence at all