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Most critically, berberine is a strong inhibitor of several cytochrome P450 liver enzymes, specifically CYP3A4 and CYP2D6

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This review critically discusses the potential of ANGPTL4 as a biomarker of DKD and explains mechanistically how does tubule-specific and podocyte-specific ANGPTL4 lead to lipid load, mitochondrial damage, inflammation and defective lipid metabolism, and accumulative effects accelerate the fibrogenesis process in diabetic kidney

Best Pract Res Clin Rheumatol (2018) 32:17487