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An International university study found B12 reduces CIN incidence in chemotherapy patients

You're more likely to have vitamin B12 deficiency if you have a medical condition where your body can't absorb B12 or you follow a strict vegan diet

Yes, when given correctly, B12 injections are considered very safe

Front Oncol 3:211 Weis S et al (2004) Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

(2021) This placebo-controlled clinical study tested copper tripeptide serum in a double-blind design, providing the gold-standard clinical evidence that followed from this laboratory foundation