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Ferroptosis plays a very important role in the pathogenesis of GO (81)

( A , B ) Breeding trial data from doxorubicin (Dox) treatment as per Fig

However, despite the widespread use of in vitro and in vivo modelssuch as transgenic animal models and brain organoidsto investigate the effects of natural compounds, these systems often fall short in capturing the full complexity of late-onset Alzheimers disease (LOAD)

However, physiological does not mean inevitable

One trial examined the effect of using vitamin E supplements (for a mean of 14 months) on memory performance in patients with early, untreated Parkinsons disease