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Abstract Insomnia is a ubiquitous complaint among many people worldwide, significantly impacting cognition, mood, and overall well-being

It has been shown to stimulate the release of brain-derived neurotrophic factor (BDNF), a protein that plays a crucial role in the survival of neurons and the growth of new neurons and synapses

Other post-translational regulators including Casein kinase II (CKII), PI3-kinase (PI3K), and c-Jun N-terminal kinases (JNKs) have also been implicated in modifying the cellular circadian clock, and may be critical for precise control of cellular circadian rhythms

2006;291(3):R491-511

The pause is what keeps the protocol delivering across multiple cycles