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Changes in gut barrier permeability can expose the host to microbial components that amplify low-grade inflammation, ultimately reducing the sensitivity of enteroendocrine signaling pathways such as GLP-1

W.TanakaN.GonzalezF

There may also be a novel non-enzymatic effect of GSTP, which plays an important role in the regulation of the classical ER signaling pathway by modification of transcriptional cofactors, such as receptor interacting protein 140 (163)