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Research studies have shown that it can be measured in human cerebrospinal fluid and post-mortem brain tissue samples 273 and is readily accessible to the brains of mice 274 (Table 2)272, 273, 274

These results suggest that CO favours the six-coordinate form of haem and interferes with the haem-mediated dimerization of PGRMC1

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As expected, Gclc -deficient mice showed lower frequencies of MZP compared to control mice (Fig